• Health

    LC-MS Method Development and Validation in Pharmaceutical Analysis: Meeting Regulatory Standards

    Liquid chromatography-mass spectrometry (LC-MS) is a robust tool that combines chromatographic separation with mass spectrum detection. This technique involves high-resolution separation of study compounds followed by specific and sensitive detection through MS units. Mass spectrometers are robust detection units for determining the structural and elemental composition of a sample. Therefore, LC-MS has numerous applications, such as bioavailability studies. But what is bioavailability? Bioavailability is the amount of a drug compound available at the site of action. LC-MS has a specific role in pharmaceutical analysis. Besides, advanced hyphenated techniques such as LC-MS/MS analysis have further skyrocketed their applications in pharmaceutical studies.…