• Health

    Advancements in LC-MS Method Validation: Ensuring Reliability in Analytical Results

    Liquid chromatography-mass spectrometry (LC-MS) assay is a robust tool for detecting and quantifying analytes in biomedical, analytical, and pharmaceutical analysis. It can detect a wide variety of analytes, including drug compounds, metabolites, impurities, and proteins, in a wide range of sample matrices. Hence, they have multiple applications, such as multiplex cytokine analysis. With an increased demand in pharmaceutical testing, LC-MS sample analysis will see exponential growth. Besides tandem approaches such as LC-MS/MS analysis, LC-MS assays are seeing a rising demand in drug testing and evaluation.  Robust LC-MS method development and validation protocols are critical for ensuring reliability in generated results.…

  • Health

    LC-MS Method Development and Validation in Pharmaceutical Analysis: Meeting Regulatory Standards

    Liquid chromatography-mass spectrometry (LC-MS) is a robust tool that combines chromatographic separation with mass spectrum detection. This technique involves high-resolution separation of study compounds followed by specific and sensitive detection through MS units. Mass spectrometers are robust detection units for determining the structural and elemental composition of a sample. Therefore, LC-MS has numerous applications, such as bioavailability studies. But what is bioavailability? Bioavailability is the amount of a drug compound available at the site of action. LC-MS has a specific role in pharmaceutical analysis. Besides, advanced hyphenated techniques such as LC-MS/MS analysis have further skyrocketed their applications in pharmaceutical studies.…